MD-PhD student publications hit record peak amid COVID-19 pandemic

Student outputs rise to record-high 33 health research publications amid the COVID-19 pandemic in 2020 and continue to climb with 22 articles published within the first four months of 2021, the MD-PhD in Molecular Medicine Program reports.

From the initial student publications in 2014, the number of research articles published with a UP College of Medicine-affiliated MD-PhD trainee or alumni reached 100 this year. This is a program milestone,” reported MD-PhD Program Coordinator Dr. Leslie Michelle Dalmacio and MD-PhD scholar Dr. Raniv Rojo.

Aiming to train research-oriented aspiring physicians and increase the pool of experts in biomedical research, the MD-PhD in Molecular Medicine Scholarship Program is the first and only dual degree program offered in the Philippines. It is a joint initiative of the Department of Science and Technology (DOST), Science Education Institute (SEI) through the Philippine Council for Health Research and Development (PCHRD), and the University of the Philippines (UP) College of Medicine.

The student outputs from the research courses are presented in various local and international science forums for dissemination and vetting as part of the program’s mentoring, with more substantial outputs being published.

The DOST-PCHRD is very proud of our MD-PhD scholars for reaching this milestone at a time where the country is battling with a pandemic. This is proof that investing in education has a transformative power in boosting research and innovation for societal development,” says PCHRD Executive Director Jaime Montoya.

The PCHRD acknowledges the productivity of the MD-PhD students as shown below:

Title MD-PhDs in Publication DOI/URL
Development of a loop-mediated isothermal amplification assay for detection of Trichomonas vaginalis Reyes, John Carlo B. https://doi.org/10.1016/j.diagmicrobio.2014.03.016
Leptospira-rat-human relationship in Luzon, Philippines Zamora, Pia Regina Fatima C. https://doi.org/10.1016/j.micinf.2014.07.001
Crude anthocyanin extract (CAE) from Ballatinao black rice hastens regeneration in Dugesia hymanae Quebral, Elgin Paul B. https://www.jpbms.info/index.php?option=com_docman&task=doc_download&gid=1206&Itemid=48
Not all Taua-tauas are alike: a morphological, molecular genetic, phytochemical, and anti-thrombocytopenic profiling of different Euphorbia hirta Linn. plants from the Philippines de Paz, Sheriah Laine M.;
Sumalde, Angelo Augusto M.;
Cruz, Criselda Jean G.;
Robles, Joyce Ann H.
https://pjhrd.upm.edu.ph/index.php/main/article/view/26/0
The validity and applicability of loop-mediated isothermal amplification (LAMP) in the diagnosis of malaria in the Philippines Poblete, Jonnel B. https://pjhrd.upm.edu.ph/index.php/main/article/view/25
Crude anthocyanin extract (CAE) from Ballatinao black rice reduces acute lead toxicity in Daphnia magna Ona, Kevin Austin L. http://www.sciepub.com/JEPHH/abstract/4074
Epidemiologic study of Blastocystis infection in an urban community in the Philippines Cadacio, Jessa Louise C. https://doi.org/10.1155/2015/894297
Bioactivity of crude ethanolic and hexane extracts from Sargassum siliquosum JG agardh against fish pathogens Tantengco, Ourlad Alzeus G. https://doi.org/10.12692/ijb%2F6.9.55-61
Serologic characterization of leptospira among rats trapped in selected public markets in Iloilo City, Philippines Zamora, Pia Regina Fatima C. https://doi.org/10.47895/amp.v49i4.910
Cytotoxic activity of crude extracts and fractions from Premna odorata (Blanco), Artocarpus camansi (Blanco) and Gliricidia sepium (Jacq.) against selected human cancer cell lines Tantengco, Ourlad Alzeus G. https://doi.org/10.1016/j.apjtb.2015.09.011
Subtype analysis of Blastocystis sp. isolates from human and canine hosts in an urban community in the Philippines Reyes, John Carlo B. https://doi.org/10.1016/j.parint.2016.02.009
Effect of Lactobacillus plantarum BS25 on cholesterol levels in vitro and in BALB/c mice (Mus musculus l.) Tumampo, Cherie Joy F. https://pjhrd.upm.edu.ph/index.php/main/article/view/104
Schistosomiasis in the Philippines: Challenges and some successes in control Tabios, Ian Kim B. https://www.tm.mahidol.ac.th/seameo/2016-47-4/11-CPH1413p651.pdf
Antibacterial activity of Vitex parviflora A. Juss. and Cyanthillium cinereum (L.) H. Rob. against human pathogens Tantengco, Ourlad Alzeus G. https://doi.org/10.1016/S2222-1808(16)61173-8
Nephroprotective Effects of Imperata cylindrica Root Aqueous Extract (ICRAE) on Sprague-Dawley Rats with Gentamicin-induced Acute Kidney Injury Poblete, Jonnel B.;
Santos, Bobbie Marie M.
https://pjhrd.upm.edu.ph/index.php/main/article/view/164
Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition Manalo, Rafael Vincent M. https://doi.org/10.3390/biomedicines5020017
The Anti-Asthmatic Effect of the Combined Yerba Buena (Mentha arvensis Linn.) and Oregano (Coleus amboinicus Lour.) Leaves in BALB/c Mice Model of Allergic Asthma Robles, Joyce Ann H. https://doi.org/10.47895/amp.v51i2.589
Association of rs17095355 Polymorphism and Extrahepatic Biliary Atresia among Filipinos Climacosa, Fresthel Monica M. https://doi.org/10.47895/amp.v51i3.547
CD14/-159 and TNFα/-308 Promoter Polymorphisms are not associated with Development of Idiopathic Neonatal Hepatitis among Filipinos San Juan, Florence Giannina F.;
Villanueva, Annavi Marie G.
https://doi.org/10.47895/amp.v51i3.553
Molecular interactions with redox sites and salt bridges modulate the anti-aggregatory effect of flavonoid, tannin and cardenolide moieties against amyloid-beta (1-42) in silico Manalo, Rafael Vincent M. https://doi.org/10.1007/s40203-017-0033-1
The differential effects of atorvastatin co-administered with ampicillin on the bacterial growth and biofilm formation of Staphylococcus aureus Manalo, Rafael Vincent M.;
Josol, Vivien D.
https://doi.org/10.1016/j.cmrp.2017.08.002
Anti-staphylococcal and antioxidant properties of crude ethanolic extracts of macrofungi collected from the Philippines Tantengco, Ourlad Alzeus G. http://dx.doi.org/10.5530/pj.2018.1.19
Anastasis and the ER stress response: solving the paradox of the unfolded protein response in cancer Manalo, Rafael Vincent M. https://doi.org/10.1016/j.mehy.2017.09.013
Isolation and genetic detection of pathogenic Leptospira spp. from environmental soils and water in Central Luzon, Philippines Tantengco, Ourlad Alzeus G. https://doi.org/10.12980/APJTD.7.2017D7-220
Genetic comparison of Oncomelania hupensis quadrasi (Möllendorf, 1895) (Gastropoda: Pomatiopsidae), the intermediate host of Schistosoma japonicum in the Philippines, based on 16S ribosomal RNA sequence Tabios, Ian Kim B. https://journals.upd.edu.ph/index.php/sciencediliman/article/view/5805
Ethnomycological survey of macrofungi utilized by Ayta communities in Bataan, Philippines Tantengco, Ourlad Alzeus G. https://www.creamjournal.org/pdf/CREAM_8_1_9.pdf
Caffeine protects dopaminergic neurons from dopamine-induced neurodegeneration via synergistic adenosine-dopamine D2-like receptor interactions in transgenic Caenorhabditis elegans Manalo, Rafael Vincent M. https://doi.org/10.3389/fnins.2018.00137
The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology Manalo, Rafael Vincent M. https://doi.org/10.1016/j.ejmhg.2017.07.004
Erythromycin exposure disrupts the life cycle stages of Aedes aegypti L. (Diptera: Culicidae) Asis, Joannes Luke B. https://doi.org/10.1007/s11270-018-3811-4
Garcinia binucao crude ethanolic leaf extract prevents alcoholinduced neurotoxic effects on learning, short-term memory, and motor functions in Drosophila melanogaster Tantengco, Ourlad Alzeus G.;
Tan, Joanne Jennifer E.
https://www.japsonline.com/abstract.php?article_id=2747&sts=2
Medical students career choices and perceptions in family medicine and primary care Tabios, Ian Kim B.;
Tantengco, Ourlad Alzeus G.
https://www.researchgate.net/publication/328281251_Medical_Students_Career_Choices_and_Perceptions_in_Family_Medicine_and_Primary_Care
Type II restriction modification system in Ureaplasma parvum OMC-P162 strain Tantengco, Ourlad Alzeus G. https://doi.org/10.1371/journal.pone.0205328
Ethnobotanical survey of medicinal plants used by Ayta communities in Dinalupihan, Bataan, Philippines Tantengco, Ourlad Alzeus G. http://dx.doi.org/10.5530/pj.2018.5.145
Sex differences in the effects of Auricularia auricula-judae ethanolic extracts on the lifespan of Drosophila melanogaster during stress and non-stress conditions Tantengco, Ourlad Alzeus G. https://www.japsonline.com/abstract.php?article_id=2767
Antifungal activity of crude glycolated extracts of Solanum tuberosum L. (white potato) peelings against Candida and Aspergillus species Tumampo, Cherie Joy F. https://doi.org/10.47895/amp.v53i1.220
Exposure-dependent antimicrobial activity and oxidative properties of polymer-based graphene oxide nanocomposites Perez, Joy Vanessa D.;
Rojo, Raniv D.
https://doi.org/10.4028/www.scientific.net/MSF.947.13
Infection rate of Schistosoma japonicum in the snail Oncomelania hupensis quadrasi in endemic villages in the Philippines: need for snail surveillance technique Tabios, Ian Kim B.;
Gampoy, Eloina Faye S.
https://msptm.org/files/Vol36No2/402-411-Fornillos-RJC.pdf
Association of PIK3CA and MDM2 SNP309 with cervical squamous cell carcinoma in a Philippine population Tantengco, Ourlad Alzeus G. https://doi.org/10.31557/apjcp.2019.20.7.2103
Analysis of environmental DNA and edaphic factors for the detection of the snail intermediate host Oncomelania hupensis quadrasi Tabios, Ian Kim B. https://doi.org/10.3390/pathogens8040160
Current understanding and treatment of intra-amniotic infection with Ureaplasma spp Tantengco, Ourlad Alzeus G. https://doi.org/10.1111/jog.14052
A case series of the dynamics of lipid mediators in patients with sepsis Tantengco, Ourlad Alzeus G. https://doi.org/10.1002/ams2.443
Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines Tabios, Ian Kim B. https://doi.org/10.1371/journal.pone.0224617
Current status of neglected tropical diseases (NTDs) in the Philippines Tabios, Ian Kim B. https://doi.org/10.1016/j.actatropica.2019.105284
Cytosolic non-vesicular dopamine accumulation as the predominant mechanism for developing non-DOPA responsive parkinsonism in late-stage Huntington disease Manalo, Rafael Vincent M. https://doi.org/10.1016/j.mehy.2019.109377
Mutagenicity of Bulk, Aqueous and Organic Partitions of Air Particulate Matter in Differentially Ventilated Wards in a Public Urban Hospital Nakpil, Aurora S. https://neptjournal.com/upload-images/NL-72-48-(46)D-843.pdf
Fully automated preparation of 68 Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications Rojo, Raniv D. https://doi.org/10.1016/j.apradiso.2019.108936
The genetics of bipolar disorder Gordovez, Francis James A. https://doi.org/10.1038/s41380-019-0634-7
First COVID-19 infections in the Philippines: a case report Villanueva, Annavi Marie G. https://dx.doi.org/10.1186%2Fs41182-020-00203-0
Antiviral effect of crude aqueous extracts from ten Philippine medicinal plants against Zika virus Vista, Fatima Ericka S. https://doi.org/10.47895/amp.v54i2.1501
A human erythrocyte-based haemolysis assay for the evaluation of human complement activity King, Ruby Ann N.;
Climacosa, Fresthel Monica M.;
Santos, Bobbie Marie M.
https://doi.org/10.1177/0261192920953170
COVID-19 screening on a tuberculosis ward in Manila, the Philippines Villanueva, Annavi Marie G. https://doi.org/10.1016/j.jctube.2020.100167
Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M Poblete, Josept Mari S. https://doi.org/10.1152/ajpendo.00174.2019
Oncomelania hupensis quadrasi: snail intermediate host of Schistosoma japonicum in the Philippines Tabios, Ian Kim B. https://doi.org/10.1016/j.actatropica.2020.105547
Epidemiological and clinical characteristics of patients with suspected COVID-19 admitted in Metro Manila, Philippines Villanueva, Annavi Marie G. https://doi.org/10.1186/s41182-020-00241-8
In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model Perez, Joy Vanessa D. https://doi.org/10.1039/d0bm00414f
Novel variants in hearing loss Genes and associations with audiometric thresholds in a multi-ethnic cohort of US patients with cochlear implants Sumalde, Angelo Augusto M. https://doi.org/10.1097/mao.0000000000002671
Detection of human pegivirus (HPgV) infection among Filipino children with decompensated liver disease secondary to biliary cirrhosis and liver transplant pediatric patients Aquino, Inah Marie C. https://doi.org/10.47895/amp.v54i4.1897
COVID-19 screening for healthcare workers in a tertiary infectious diseases referral hospital in Manila, the Philippines Villanueva, Annavi Marie G. https://doi.org/10.4269/ajtmh.20-0715
Prevalence of urolithiasis by ultrasonography among patients with gout: a cross-sectional study from the UP-Philippine General Hospital Abrilla, Aedrian A. https://doi.org/10.2147/rru.s268700
Genomic and proteomic mutation landscapes of SARS‐CoV‐2 Badua, Christian Luke D.C;
Baldo, Karol Ann T.
https://doi.org/10.1002/jmv.26548
Detection of Vibrio parahaemolyticus in fish samples from selected wet markets in Laguna, Philippines, using loop-mediated isothermal amplification (LAMP) and real-time polymerase chain reaction (qPCR) Teh, Treena Rica D. https://www.philsciletters.net/2020-special-issue-8/
Prevalence of Entamoeba histolytica and Entamoeba dispar among residents of an urban slum area in Manila, Philippines as detected by the polymerase chain reaction Aquino, Inah Marie C. https://annals-parasitology.eu/go.live.php/download_default/D1729/prevalence-of-ientamoeba-histolyticai-and-ientamoeba-dispari-among-residents-of-an-urban-slum-area-in-manila-philippines-as-detected-by-the-polymerase-chain-reaction.html
Understanding nanoparticle toxicity to direct a safe-by-design approach in cancer nanomedicine Perez, Joy Vanessa D. https://doi.org/10.3390/nano10112186
Effects of a gestational level of estradiol on cellular transition, migration, and inflammation in cervical epithelial and stromal cells Tantengco, Ourlad Alzeus G. https://doi.org/10.1111/aji.13370
Environmental pollutant exposure can exacerbate COVID-19 neurologic symptoms Reyes, Michael Sigfrid S. https://doi.org/10.1016/j.mehy.2020.110136
Development and characterization of polymeric peptides for antibody tagging of bacterial targets Climacosa, Fresthel Monica M.;
King, Ruby Ann N.;
Santos, Bobbie Marie M.
https://doi.org/10.2174/0929866527666200427212940
Hydranencephaly: clinical features and survivorship in a retrospective cohort Reyes, John Carlo B. https://doi.org/10.1016/j.wneu.2020.09.029
Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone fibrous composites Perez, Joy Vanessa D.;
Rojo, Raniv D.
https://doi.org/10.1016/j.mtla.2020.100874
Primary Care Orientation of Family Practice in the Philippines: Cross-sectional Study in Pilot Sites Tabios, Ian Kim B. https://www.researchgate.net/profile/Leilanie-Nicodemus-2/publication/348758671_Primary_Care_Orientation_of_Family_Practice_in_the_Philippines_Cross-sectional_Study_in_Pilot_Sites/links/600fb2a4299bf14088c09375/Primary-Care-Orientation-of-Family-Practice-in-the-Philippines-Cross-sectional-Study-in-Pilot-Sites.pdf
Identification of Class I HLA alleles in anonymized cell therapy specimens through real-time PCR with meltcurve analysis Tan, Joanne Jennifer E. https://www.psbmb.org/uploads/1/0/1/3/101342864/article_4_january-december_2020_volume_1_issue_1_2.pdf
Contractile function of the cervix plays a role in normal and pathological pregnancy and parturition Tantengco, Ourlad Alzeus G. https://doi.org/10.1016/j.mehy.2020.110336
Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson’s disease Manalo, Rafael Vincent M. https://doi.org/10.1080/13880209.2020.1791192
Policy analysis on determining hospital bed capacity in light of Universal Health Care Buan, Ara Karizza G. https://doi.org/10.47895/amp.v54i6.2596
A call for an evidence-informed criteria selection to guide equitable health investments in the era of Universal Health Care: policy analysis Buan, Ara Karizza G. https://doi.org/10.47895/amp.v54i6.2587
Addressing primary care inequities in underserved areas of the Philippines: a review Buan, Ara Karizza G. https://doi.org/10.47895/amp.v54i6.2578
In silico prediction of SARS-CoV-2 epitopes for vaccine development Marco, Kitz Paul D.;
Llagas, Julia Patricia B.
https://pjhrd.upm.edu.ph/index.php/main/article/view/382
An optimized de Man Rogosa Sharpe-McCoy’s 5A medium formulation for the in vitro screening of cytotoxic effects by probiotic candidates against colorectal cancer cells Badua, Christian Luke D.C https://www.philsciletters.net/2020-139/
Molecular epidemiology of coxsackievirus A6 causing hand-foot-and-mouth disease in the Philippines, 2012–2017 Climacosa, Fresthel Monica M. https://doi.org/10.1016/j.ijid.2020.09.1299
Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions Perez, Joy Vanessa D. https://doi.org/10.1002/mp.14601
Recent advances in nanomedicine for the diagnosis and treatment of prostate cancer bone metastasis Perez, Joy Vanessa D.;
Rojo, Raniv D.
https://doi.org/10.3390/molecules26020384
Effects of brief adjunctive metformin therapy in virologically suppressed HIV-infected adults on polyfunctional HIV-specific CD8 T cell responses to PD-L1 blockade Padua, Ana Joy P. https://doi.org/10.1089/aid.2020.0172
Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains Cruz, Christian Alfredo K. https://doi.org/10.1016/j.tranon.2020.100940
The role of genital mycoplasma infection in female infertility: a systematic review and meta-analysis Tantengco, Ourlad Alzeus G. https://doi.org/10.1111/aji.13390
Anti-inflammatory drugs and the renin-angiotensin-aldosterone system: current knowledge and potential effects on early SARS-CoV-2 infection Manalo, Rafael Vincent M. https://doi.org/10.1016/j.virusres.2020.198190
Barriers to online learning in the time of COVID-19: a national survey of medical students in the Philippines Reyes, John Carlo B. https://doi.org/10.1007/s40670-021-01231-z
Virgin coconut oil attenuates deficits in rats undergoing transient cerebral ischemia Climacosa, Fresthel Monica M. https://doi.org/10.47895/amp.v55i1.2938
Philippine rice wine (tapuy) made from Ballatinao black rice and traditional starter culture (Bubod) showed high alcohol content, total phenolic content, and antioxidant activity Dela Rosa, Jared Gabriel L. https://doi.org/10.1590/fst.45120
Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice Girasol, Mark John G.;
Grecia, Lordom Reno C.
https://doi.org/10.1016/j.exppara.2020.108049
Direct saliva versus conventional nasopharyngeal swab qRT-PCR to diagnose SARS – CoV2: validity study Abrilla, Aedrian A. https://doi.org/10.9734/ajrid/2021/v6i230193
Cactus: chemical, nutraceutical composition and potential bio-pharmacological properties Tantengco, Ourlad Alzeus G. https://doi.org/10.1002/ptr.6889
Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy Tantengco, Ourlad Alzeus G. https://doi.org/10.1093/biolre/ioab058
If not COVID-19 what is it? Analysis of COVID-19 versus common respiratory viruses among symptomatic health care workers in a tertiary infectious disease referral hospital in Manila, Philippines Villanueva, Annavi Marie G. https://doi.org/10.3390/tropicalmed6010039
Molecular epidemiologic analysis of Mycobacterium tuberculosis among prison inmates in selected prisons in the Philippines Malabad, John Carlo M. https://philjournalsci.dost.gov.ph/images/pdf/pjs_pdf/vol150no2/molecular_epidemiologic_analysis_of_mycobacterium_tuberculosis_.pdf
Molecular epidemiology of Mycobacterium tuberculosis in adult Filipino TB-HIV co-infected patients Malabad, John Carlo M. https://doi.org/10.5588/ijtld.20.0878
Organ-on-chip of the cervical epithelial layer: A platform to study normal and pathological cellular remodeling of the cervix Tantengco, Ourlad Alzeus G. https://doi.org/10.1096/fj.202002590rrr
Progesterone alters human cervical epithelial and stromal cell transition and migration: Implications in cervical remodeling during pregnancy and parturition Tantengco, Ourlad Alzeus G. https://doi.org/10.1016/j.mce.2021.111276
Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice Rojo, Raniv D.;
Perez, Joy Vanessa D.
https://doi.org/10.1080/02656736.2021.1914873
Prevalence and prognostic associations of cardiac abnormalities among hospitalized patients with COVID‐19: a systematic review and meta‐analysis Lintao, Ryan C.V. https://doi.org/10.1038/s41598-021-87961-x
Efficacy of fluvastatin and aspirin for prevention of hormonally insensitive breast cancer Rojo, Raniv D. https://doi.org/10.1007/s10549-021-06229-0
Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System Tantengco, Ourlad Alzeus G.;
Robles, Joyce Ann H.
https://doi.org/10.3390/plants10050846
Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials Abrilla, Aedrian A. https://doi.org/10.1016/j.diabres.2021.108824
Characteristics and Factors Associated with Mortality of 200 COVID-19 Patients at a Philippine COVID-19 Tertiary Referral Center Poblete, Jonnel B. https://doi.org/10.47895/amp.v55i2.2845

 

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