The ASEAN Dx Initiative is set to launch the first installment of the ASEAN Dx Preparedness Webinar Series discussing “Direct PCR as an Alternative Platform to Conventional PCR” this 28th May 2021, 9AM to 10:20AM.

Endorsed by the ASEAN Committee of Science, Technology and Innovation, the ASEAN Dx Initiative focuses on capacity building amongst member countries; which has become a priority for the region with the ongoing pandemic.

The webinar will discuss the use of direct PCR as an alternative platform for lab-based diagnostics and how it can manage COVID-19 testing demands with the following experts:

1. Dr Kristine Alvarado-Dela Cruz Pediatrics, Infectious Diseases, Head of Microbiology, Research Institute for Tropical Medicine, Philippines

2. Dr Eric Vail - Director, Molecular Pathology, Cedars-Sinai Medical Centre, United States

3. Dr Wong Mun Yew - Chief Executive Officer & Founder, Asia Genomics, Singapore

4. Dr Joseph Yao - Associate Professor, Laboratory Medicine and Pathology, Mayo Clinic, United States

The webinar is CME accredited. 

 

To register, visit: tinyurl.com/aseandxdirectpcr.


Student outputs rise to record-high 33 health research publications amid the COVID-19 pandemic in 2020 and continue to climb with 22 articles published within the first four months of 2021, the MD-PhD in Molecular Medicine Program reports.

From the initial student publications in 2014, the number of research articles published with a UP College of Medicine-affiliated MD-PhD trainee or alumni reached 100 this year. This is a program milestone,” reported MD-PhD Program Coordinator Dr. Leslie Michelle Dalmacio and MD-PhD scholar Dr. Raniv Rojo.

Aiming to train research-oriented aspiring physicians and increase the pool of experts in biomedical research, the MD-PhD in Molecular Medicine Scholarship Program is the first and only dual degree program offered in the Philippines. It is a joint initiative of the Department of Science and Technology (DOST), Science Education Institute (SEI) through the Philippine Council for Health Research and Development (PCHRD), and the University of the Philippines (UP) College of Medicine.

The student outputs from the research courses are presented in various local and international science forums for dissemination and vetting as part of the program's mentoring, with more substantial outputs being published. 

The DOST-PCHRD is very proud of our MD-PhD scholars for reaching this milestone at a time where the country is battling with a pandemic. This is proof that investing in education has a transformative power in boosting research and innovation for societal development,” says PCHRD Executive Director Jaime Montoya.

The PCHRD acknowledges the productivity of the MD-PhD students as shown below:


Title

MD-PhDs in Publication

DOI/URL

Development of a loop-mediated isothermal amplification assay for detection of Trichomonas vaginalis

Reyes, John Carlo B.

https://doi.org/10.1016/j.diagmicrobio.2014.03.016

Leptospira-rat-human relationship in Luzon, Philippines

Zamora, Pia Regina Fatima C.

https://doi.org/10.1016/j.micinf.2014.07.001

Crude anthocyanin extract (CAE) from Ballatinao black rice hastens regeneration in Dugesia hymanae

Quebral, Elgin Paul B.

https://www.jpbms.info/index.php?option=com_docman&task=doc_download&gid=1206&Itemid=48

Not all Taua-tauas are alike: a morphological, molecular genetic, phytochemical, and anti-thrombocytopenic profiling of different Euphorbia hirta Linn. plants from the Philippines

de Paz, Sheriah Laine M.;
Sumalde, Angelo Augusto M.;
Cruz, Criselda Jean G.;
Robles, Joyce Ann H.

https://pjhrd.upm.edu.ph/index.php/main/article/view/26/0

The validity and applicability of loop-mediated isothermal amplification (LAMP) in the diagnosis of malaria in the Philippines

Poblete, Jonnel B.

https://pjhrd.upm.edu.ph/index.php/main/article/view/25

Crude anthocyanin extract (CAE) from Ballatinao black rice reduces acute lead toxicity in Daphnia magna

Ona, Kevin Austin L.

http://www.sciepub.com/JEPHH/abstract/4074

Epidemiologic study of Blastocystis infection in an urban community in the Philippines

Cadacio, Jessa Louise C.

https://doi.org/10.1155/2015/894297

Bioactivity of crude ethanolic and hexane extracts from Sargassum siliquosum JG agardh against fish pathogens

Tantengco, Ourlad Alzeus G.

https://doi.org/10.12692/ijb%2F6.9.55-61

Serologic characterization of leptospira among rats trapped in selected public markets in Iloilo City, Philippines

Zamora, Pia Regina Fatima C.

https://doi.org/10.47895/amp.v49i4.910

Cytotoxic activity of crude extracts and fractions from Premna odorata (Blanco), Artocarpus camansi (Blanco) and Gliricidia sepium (Jacq.) against selected human cancer cell lines

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/j.apjtb.2015.09.011

Subtype analysis of Blastocystis sp. isolates from human and canine hosts in an urban community in the Philippines

Reyes, John Carlo B.

https://doi.org/10.1016/j.parint.2016.02.009

Effect of Lactobacillus plantarum BS25 on cholesterol levels in vitro and in BALB/c mice (Mus musculus l.)

Tumampo, Cherie Joy F.

https://pjhrd.upm.edu.ph/index.php/main/article/view/104

Schistosomiasis in the Philippines: Challenges and some successes in control

Tabios, Ian Kim B.

https://www.tm.mahidol.ac.th/seameo/2016-47-4/11-CPH1413p651.pdf

Antibacterial activity of Vitex parviflora A. Juss. and Cyanthillium cinereum (L.) H. Rob. against human pathogens

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/S2222-1808(16)61173-8

Nephroprotective Effects of Imperata cylindrica Root Aqueous Extract (ICRAE) on Sprague-Dawley Rats with Gentamicin-induced Acute Kidney Injury

Poblete, Jonnel B.;
Santos, Bobbie Marie M.

https://pjhrd.upm.edu.ph/index.php/main/article/view/164

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition

Manalo, Rafael Vincent M.

https://doi.org/10.3390/biomedicines5020017

The Anti-Asthmatic Effect of the Combined Yerba Buena (Mentha arvensis Linn.) and Oregano (Coleus amboinicus Lour.) Leaves in BALB/c Mice Model of Allergic Asthma

Robles, Joyce Ann H.

https://doi.org/10.47895/amp.v51i2.589

Association of rs17095355 Polymorphism and Extrahepatic Biliary Atresia among Filipinos

Climacosa, Fresthel Monica M.

https://doi.org/10.47895/amp.v51i3.547

CD14/-159 and TNFα/-308 Promoter Polymorphisms are not associated with Development of Idiopathic Neonatal Hepatitis among Filipinos

San Juan, Florence Giannina F.;
Villanueva, Annavi Marie G.

https://doi.org/10.47895/amp.v51i3.553

Molecular interactions with redox sites and salt bridges modulate the anti-aggregatory effect of flavonoid, tannin and cardenolide moieties against amyloid-beta (1-42) in silico

Manalo, Rafael Vincent M.

https://doi.org/10.1007/s40203-017-0033-1

The differential effects of atorvastatin co-administered with ampicillin on the bacterial growth and biofilm formation of Staphylococcus aureus

Manalo, Rafael Vincent M.;
Josol, Vivien D.

https://doi.org/10.1016/j.cmrp.2017.08.002

Anti-staphylococcal and antioxidant properties of crude ethanolic extracts of macrofungi collected from the Philippines

Tantengco, Ourlad Alzeus G.

http://dx.doi.org/10.5530/pj.2018.1.19

Anastasis and the ER stress response: solving the paradox of the unfolded protein response in cancer

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.mehy.2017.09.013

Isolation and genetic detection of pathogenic Leptospira spp. from environmental soils and water in Central Luzon, Philippines

Tantengco, Ourlad Alzeus G.

https://doi.org/10.12980/APJTD.7.2017D7-220

Genetic comparison of Oncomelania hupensis quadrasi (Möllendorf, 1895) (Gastropoda: Pomatiopsidae), the intermediate host of Schistosoma japonicum in the Philippines, based on 16S ribosomal RNA sequence

Tabios, Ian Kim B.

https://journals.upd.edu.ph/index.php/sciencediliman/article/view/5805

Ethnomycological survey of macrofungi utilized by Ayta communities in Bataan, Philippines

Tantengco, Ourlad Alzeus G.

https://www.creamjournal.org/pdf/CREAM_8_1_9.pdf

Caffeine protects dopaminergic neurons from dopamine-induced neurodegeneration via synergistic adenosine-dopamine D2-like receptor interactions in transgenic Caenorhabditis elegans

Manalo, Rafael Vincent M.

https://doi.org/10.3389/fnins.2018.00137

The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.ejmhg.2017.07.004

Erythromycin exposure disrupts the life cycle stages of Aedes aegypti L. (Diptera: Culicidae)

Asis, Joannes Luke B.

https://doi.org/10.1007/s11270-018-3811-4

Garcinia binucao crude ethanolic leaf extract prevents alcoholinduced neurotoxic effects on learning, short-term memory, and motor functions in Drosophila melanogaster

Tantengco, Ourlad Alzeus G.;
Tan, Joanne Jennifer E.

https://www.japsonline.com/abstract.php?article_id=2747&sts=2

Medical students career choices and perceptions in family medicine and primary care

Tabios, Ian Kim B.;
Tantengco, Ourlad Alzeus G.

https://www.researchgate.net/publication/328281251_Medical_Students_Career_Choices_and_Perceptions_in_Family_Medicine_and_Primary_Care

Type II restriction modification system in Ureaplasma parvum OMC-P162 strain

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1371/journal.pone.0205328

Ethnobotanical survey of medicinal plants used by Ayta communities in Dinalupihan, Bataan, Philippines

Tantengco, Ourlad Alzeus G.

http://dx.doi.org/10.5530/pj.2018.5.145

Sex differences in the effects of Auricularia auricula-judae ethanolic extracts on the lifespan of Drosophila melanogaster during stress and non-stress conditions

Tantengco, Ourlad Alzeus G.

https://www.japsonline.com/abstract.php?article_id=2767

Antifungal activity of crude glycolated extracts of Solanum tuberosum L. (white potato) peelings against Candida and Aspergillus species

Tumampo, Cherie Joy F.

https://doi.org/10.47895/amp.v53i1.220

Exposure-dependent antimicrobial activity and oxidative properties of polymer-based graphene oxide nanocomposites

Perez, Joy Vanessa D.;
Rojo, Raniv D.

https://doi.org/10.4028/www.scientific.net/MSF.947.13

Infection rate of Schistosoma japonicum in the snail Oncomelania hupensis quadrasi in endemic villages in the Philippines: need for snail surveillance technique

Tabios, Ian Kim B.;
Gampoy, Eloina Faye S.

https://msptm.org/files/Vol36No2/402-411-Fornillos-RJC.pdf

Association of PIK3CA and MDM2 SNP309 with cervical squamous cell carcinoma in a Philippine population

Tantengco, Ourlad Alzeus G.

https://doi.org/10.31557/apjcp.2019.20.7.2103

Analysis of environmental DNA and edaphic factors for the detection of the snail intermediate host Oncomelania hupensis quadrasi

Tabios, Ian Kim B.

https://doi.org/10.3390/pathogens8040160

Current understanding and treatment of intra-amniotic infection with Ureaplasma spp

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1111/jog.14052

A case series of the dynamics of lipid mediators in patients with sepsis

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1002/ams2.443

Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines

Tabios, Ian Kim B.

https://doi.org/10.1371/journal.pone.0224617

Current status of neglected tropical diseases (NTDs) in the Philippines

Tabios, Ian Kim B.

https://doi.org/10.1016/j.actatropica.2019.105284

Cytosolic non-vesicular dopamine accumulation as the predominant mechanism for developing non-DOPA responsive parkinsonism in late-stage Huntington disease

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.mehy.2019.109377

Mutagenicity of Bulk, Aqueous and Organic Partitions of Air Particulate Matter in Differentially Ventilated Wards in a Public Urban Hospital

Nakpil, Aurora S.

https://neptjournal.com/upload-images/NL-72-48-(46)D-843.pdf

Fully automated preparation of 68 Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications 

Rojo, Raniv D.

https://doi.org/10.1016/j.apradiso.2019.108936

The genetics of bipolar disorder

Gordovez, Francis James A.

https://doi.org/10.1038/s41380-019-0634-7

First COVID-19 infections in the Philippines: a case report

Villanueva, Annavi Marie G.

https://dx.doi.org/10.1186%2Fs41182-020-00203-0

Antiviral effect of crude aqueous extracts from ten Philippine medicinal plants against Zika virus

Vista, Fatima Ericka S.

https://doi.org/10.47895/amp.v54i2.1501

A human erythrocyte-based haemolysis assay for the evaluation of human complement activity

King, Ruby Ann N.;
Climacosa, Fresthel Monica M.;
Santos, Bobbie Marie M.

https://doi.org/10.1177/0261192920953170

COVID-19 screening on a tuberculosis ward in Manila, the Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.1016/j.jctube.2020.100167

Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M

Poblete, Josept Mari S.

https://doi.org/10.1152/ajpendo.00174.2019

Oncomelania hupensis quadrasi: snail intermediate host of Schistosoma japonicum in the Philippines

Tabios, Ian Kim B.

https://doi.org/10.1016/j.actatropica.2020.105547

Epidemiological and clinical characteristics of patients with suspected COVID-19 admitted in Metro Manila, Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.1186/s41182-020-00241-8

In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model

Perez, Joy Vanessa D.

https://doi.org/10.1039/d0bm00414f

Novel variants in hearing loss Genes and associations with audiometric thresholds in a multi-ethnic cohort of US patients with cochlear implants

Sumalde, Angelo Augusto M.

https://doi.org/10.1097/mao.0000000000002671

Detection of human pegivirus (HPgV) infection among Filipino children with decompensated liver disease secondary to biliary cirrhosis and liver transplant pediatric patients

Aquino, Inah Marie C.

https://doi.org/10.47895/amp.v54i4.1897

COVID-19 screening for healthcare workers in a tertiary infectious diseases referral hospital in Manila, the Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.4269/ajtmh.20-0715

Prevalence of urolithiasis by ultrasonography among patients with gout: a cross-sectional study from the UP-Philippine General Hospital

Abrilla, Aedrian A.

https://doi.org/10.2147/rru.s268700

Genomic and proteomic mutation landscapes of SARSCoV2

Badua, Christian Luke D.C;
Baldo, Karol Ann T.

https://doi.org/10.1002/jmv.26548

Detection of Vibrio parahaemolyticus in fish samples from selected wet markets in Laguna, Philippines, using loop-mediated isothermal amplification (LAMP) and real-time polymerase chain reaction (qPCR)

Teh, Treena Rica D.

https://www.philsciletters.net/2020-special-issue-8/

Prevalence of Entamoeba histolytica and Entamoeba dispar among residents of an urban slum area in Manila, Philippines as detected by the polymerase chain reaction

Aquino, Inah Marie C.

https://annals-parasitology.eu/go.live.php/download_default/D1729/prevalence-of-ientamoeba-histolyticai-and-ientamoeba-dispari-among-residents-of-an-urban-slum-area-in-manila-philippines-as-detected-by-the-polymerase-chain-reaction.html

Understanding nanoparticle toxicity to direct a safe-by-design approach in cancer nanomedicine

Perez, Joy Vanessa D.

https://doi.org/10.3390/nano10112186

Effects of a gestational level of estradiol on cellular transition, migration, and inflammation in cervical epithelial and stromal cells

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1111/aji.13370

Environmental pollutant exposure can exacerbate COVID-19 neurologic symptoms

Reyes, Michael Sigfrid S.

https://doi.org/10.1016/j.mehy.2020.110136

Development and characterization of polymeric peptides for antibody tagging of bacterial targets

Climacosa, Fresthel Monica M.;
King, Ruby Ann N.;
Santos, Bobbie Marie M.

https://doi.org/10.2174/0929866527666200427212940

Hydranencephaly: clinical features and survivorship in a retrospective cohort 

Reyes, John Carlo B.

https://doi.org/10.1016/j.wneu.2020.09.029

Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone fibrous composites

Perez, Joy Vanessa D.;
Rojo, Raniv D.

https://doi.org/10.1016/j.mtla.2020.100874

Primary Care Orientation of Family Practice in the Philippines: Cross-sectional Study in Pilot Sites

Tabios, Ian Kim B.

https://www.researchgate.net/profile/Leilanie-Nicodemus-2/publication/348758671_Primary_Care_Orientation_of_Family_Practice_in_the_Philippines_Cross-sectional_Study_in_Pilot_Sites/links/600fb2a4299bf14088c09375/Primary-Care-Orientation-of-Family-Practice-in-the-Philippines-Cross-sectional-Study-in-Pilot-Sites.pdf

Identification of Class I HLA alleles in anonymized cell therapy specimens through real-time PCR with meltcurve analysis

Tan, Joanne Jennifer E.

https://www.psbmb.org/uploads/1/0/1/3/101342864/article_4_january-december_2020_volume_1_issue_1_2.pdf

Contractile function of the cervix plays a role in normal and pathological pregnancy and parturition

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/j.mehy.2020.110336

Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson's disease

Manalo, Rafael Vincent M.

https://doi.org/10.1080/13880209.2020.1791192

Policy analysis on determining hospital bed capacity in light of Universal Health Care

Buan, Ara Karizza G.

https://doi.org/10.47895/amp.v54i6.2596

A call for an evidence-informed criteria selection to guide equitable health investments in the era of Universal Health Care: policy analysis

Buan, Ara Karizza G.

https://doi.org/10.47895/amp.v54i6.2587

Addressing primary care inequities in underserved areas of the Philippines: a review

Buan, Ara Karizza G.

https://doi.org/10.47895/amp.v54i6.2578

In silico prediction of SARS-CoV-2 epitopes for vaccine development

Marco, Kitz Paul D.;
Llagas, Julia Patricia B.

https://pjhrd.upm.edu.ph/index.php/main/article/view/382

An optimized de Man Rogosa Sharpe-McCoy’s 5A medium formulation for the in vitro screening of cytotoxic effects by probiotic candidates against colorectal cancer cells

Badua, Christian Luke D.C

https://www.philsciletters.net/2020-139/

Molecular epidemiology of coxsackievirus A6 causing hand-foot-and-mouth disease in the Philippines, 2012–2017

Climacosa, Fresthel Monica M.

https://doi.org/10.1016/j.ijid.2020.09.1299

Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions

Perez, Joy Vanessa D.

https://doi.org/10.1002/mp.14601

Recent advances in nanomedicine for the diagnosis and treatment of prostate cancer bone metastasis

Perez, Joy Vanessa D.;
Rojo, Raniv D.

https://doi.org/10.3390/molecules26020384

Effects of brief adjunctive metformin therapy in virologically suppressed HIV-infected adults on polyfunctional HIV-specific CD8 T cell responses to PD-L1 blockade

Padua, Ana Joy P.

https://doi.org/10.1089/aid.2020.0172

Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains

Cruz, Christian Alfredo K.

https://doi.org/10.1016/j.tranon.2020.100940

The role of genital mycoplasma infection in female infertility: a systematic review and meta-analysis

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1111/aji.13390

Anti-inflammatory drugs and the renin-angiotensin-aldosterone system: current knowledge and potential effects on early SARS-CoV-2 infection

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.virusres.2020.198190

Barriers to online learning in the time of COVID-19: a national survey of medical students in the Philippines

Reyes, John Carlo B.

https://doi.org/10.1007/s40670-021-01231-z

Virgin coconut oil attenuates deficits in rats undergoing transient cerebral ischemia

Climacosa, Fresthel Monica M.

https://doi.org/10.47895/amp.v55i1.2938

Philippine rice wine (tapuy) made from Ballatinao black rice and traditional starter culture (Bubod) showed high alcohol content, total phenolic content, and antioxidant activity

Dela Rosa, Jared Gabriel L.

https://doi.org/10.1590/fst.45120

Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice

Girasol, Mark John G.;
Grecia, Lordom Reno C.

https://doi.org/10.1016/j.exppara.2020.108049

Direct saliva versus conventional nasopharyngeal swab qRT-PCR to diagnose SARS – CoV2: validity study

Abrilla, Aedrian A.

https://doi.org/10.9734/ajrid/2021/v6i230193

Cactus: chemical, nutraceutical composition and potential bio-pharmacological properties

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1002/ptr.6889

Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1093/biolre/ioab058

If not COVID-19 what is it? Analysis of COVID-19 versus common respiratory viruses among symptomatic health care workers in a tertiary infectious disease referral hospital in Manila, Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.3390/tropicalmed6010039

Molecular epidemiologic analysis of Mycobacterium tuberculosis among prison inmates in selected prisons in the Philippines

Malabad, John Carlo M.

https://philjournalsci.dost.gov.ph/images/pdf/pjs_pdf/vol150no2/molecular_epidemiologic_analysis_of_mycobacterium_tuberculosis_.pdf

Molecular epidemiology of Mycobacterium tuberculosis in adult Filipino TB-HIV co-infected patients

Malabad, John Carlo M.

https://doi.org/10.5588/ijtld.20.0878

Organ-on-chip of the cervical epithelial layer: A platform to study normal and pathological cellular remodeling of the cervix

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1096/fj.202002590rrr

Progesterone alters human cervical epithelial and stromal cell transition and migration: Implications in cervical remodeling during pregnancy and parturition

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/j.mce.2021.111276

Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice

Rojo, Raniv D.;
Perez, Joy Vanessa D.

https://doi.org/10.1080/02656736.2021.1914873

Prevalence and prognostic associations of cardiac abnormalities among hospitalized patients with COVID19: a systematic review and metaanalysis

Lintao, Ryan C.V.

https://doi.org/10.1038/s41598-021-87961-x

Efficacy of fluvastatin and aspirin for prevention of hormonally insensitive breast cancer

Rojo, Raniv D.

https://doi.org/10.1007/s10549-021-06229-0

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Tantengco, Ourlad Alzeus G.;
Robles, Joyce Ann H.

https://doi.org/10.3390/plants10050846

Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Abrilla, Aedrian A.

https://doi.org/10.1016/j.diabres.2021.108824

Characteristics and Factors Associated with Mortality of 200 COVID-19 Patients at a Philippine COVID-19 Tertiary Referral Center

Poblete, Jonnel B.

https://doi.org/10.47895/amp.v55i2.2845






Solving complex problems with the right partners matters.”

Deriving inspiration from her experiences in leading health research work on neurodegenerative diseases, Board Overseer of the Harvard University Atty. Geraldine Acuña-Sunshine highlighted the importance of building on strategic R&D partnerships for health in her keynote speech during the 39th anniversary of the Department of Science and Technology - Philippine Council for Health Research and Development (DOST-PCHRD) last March 17, 2021.


Atty. Acuña-Sunshine shared how her work is inspired by her brother, Dr. Patrick Acuña, who is affected by the rare Filipino disease called X-Linked Dystonia Parkinsonism (XDP). "He is the reason why I do what I do, and why I am here today,” she said.

Affecting Filipino men mostly from Region 6, XDP may cause the patient’s inability to work or move in a normal way. As a result, the patients may suffer from depression, isolation, and the loss of livelihood which may lead to  the inability to afford food and medicine, among others. This affects not only the vulnerable patients but their families and the community as well.

To help alleviate the burdens of this disease, she directs the Collaborative Center for XDP at the Massachusetts General Hospital (MGH), which seeks to understand XDP’s pathogenic mechanisms and develop cutting-edge therapies and interventions in collaboration with their network of academic, pharmaceutical and bioengineering partners. The center has made significant headway through actively funding several studies involving genomics and transcriptomics, cell and animal modeling, neuropathology and brain banking, gene regulation and epigenetics, and neuroimaging and deep brain stimulation. 

 

Through the Center, they were able to attract partners and experts including physician-scientists from University of the Philippines, Philippine Genome Center, Movement Disorder Society of the Philippines and Makati Medical Center, among other prestigious institutions. The DOST also signed a Memorandum of Understanding with the MGH, which will serve as a pathway to create a stronger, wider research network with relevant institutions at Harvard University.

Further, Atty. Acuña-Sunshine also led the establishment of the Sunshine Care Foundation which provides funding and support to research projects dedicated to neurodegenerative diseases, and provides medical care and humanitarian aid to clinical patients and affected families.

In partnership with the Philippine Genome Center (PGC) and the DOST, she also leads the study “High Throughput Prevalence Study for XDP,” which analyzes de-identified newborn blood spots to gather information on the prevalence and geographical distribution of the disease. This process is envisioned to be used as a powerful epidemiological mechanism to quantify the prevalence not only of XDP but of other genetic conditions in the country as well. Thereby helping address the limited data on the number of patients of XDP and other diseases, and contribute to crafting evidence-informed health and wellness policies.


According to Atty. Acuña-Sunshine, her endeavor in XDP research provided her three important lessons:

First, forging partnerships can make a difference in research undertakings or initiatives. “Whether it's addressing a pandemic like COVID-19 or diseases specific to the Philippines like XDP, having people with the right diversity of perspectives and expertise is key to effective and efficient problem solving,” she said. 


Second, continuing to expand scientific knowledge in a variety of fields, and investing in infrastructure and people to build their talents will also play a critical role in trying to solve healthcare problems.


Lastly, she highlighted that the Philippines can also be a model for other developing countries, in terms of developing their research approach for unique healthcare problems and advancing scientific knowledge for all.


Our work has shown that we can allocate our resources wisely, while building the science and technology infrastructure we need to meet the health challenges that are here and are yet to come,” she concludes.

___________________________________________________________________________________________________

The DOST-PCHRD celebrated its 39th anniversary last March 17, 2021 through an online webinar with the theme Strategic R&D Partnership for Global Health. Aside from Atty. Acuña-Sunshine, the webinar was also attended by other experts in the field of health research, including DOST Undersecretary for Research and Development Dr. Rowena Christina Guevara, Italian Liver Foundation Scientific Director Dr. Claudio Tiribelli, and UP Manila College of Public Health Dean Dr. Vicente Belizario Jr..

Mindanao scientists are now in anticipation of the first research center to be established in the region aimed to strengthen local response to infectious diseases, including COVID-19.

On 3 May 2021, the Department of Science and Technology and the University of the Philippines (UP) Mindanao launched AMDABiDSS-Health, or Center for Applied Modeling, Data Analytics, and Bioinformatics for Decision Support Systems in Health while observing proper precautionary measures at Malayan Colleges Mindanao with viewers supporting via Zoom.



As the first research center in the region that uses interdisciplinary quantitative approaches and improved disease surveillance techniques, the AMDABiDSS-Health is subdivided into four components:


  1. Project 1: Predictive Modeling and Viral Phylodynamic Analysis on the Spatial and Temporal Patterns of Disease Outbreaks with considerations for Control and Logistics applied in Mindanao region - aims to develop a tool that integrates mathematical and genomic approaches to predict the spread of COVID-19 in affected parts of Mindanao region
  2. Project 2: Risk Management and Enhanced Survival Analysis Integrated through Longitudinal Infectious Disease Data and Statistical Epidemiological Model using Clinical Risk Factors - aims to develop solutions and strategies to effectively manage the risks associated with COVID-19 using interdisciplinary applied modeling systems and processes
  3. Project 3: Vulnerability Assessment Tool: A Decision Support System for Pre-Emptive Preparedness on Emerging Infections Among Animal Reservoir in Urban Green Spaces - aims to develop and validate a vulnerability assessment tool for emerging infectious diseases using Davao City as a pilot model 
  4. Project 4: Integrated Wastewater-Based Epidemiology and Data Analytics for Community-Level Pathogen Surveillance and Genetic Tracking: Proof-of-Concept - aims to establish a proof-of-concept for wastewater system-based epidemiology as a complementary approach for COVID-19 surveillance with Davao City as a pilot study area 

Today is a historical day, aside from the fact that this is our program wide meeting, today is the conception anniversary of the AMDABiDSS. We became victors of circumstance as we are able to use the negative situation as an opportunity to build, unite and aid sustainable solutions to our community towards a healthier Mindanao, and even in other parts of the country. DOST-PCHRD helped us pave the way to build this dream into fruition. Kamo gyud ang nagsuporta sa amo ani,” said Dr. May Anne Mata, Program Leader of AMDABiDSS-Health and Head of Interdisciplinary Applied Mathematics Laboratory of UP Mindanao.

AMDABiDSS-Health is part of DOST’s Niche Centers in the Regions or NICER Program, one of the four components of DOST Science for Change Program that aims to establish R&D centers in the regions to promote regional development.

Through DOST’s NICER Program, we aim to catalyze regional development by capacitating institutions to make significant improvements through research. We congratulate UP Mindanao for finally realizing AMDABiDSS-Health after months of hard work and dedication. Thank you for being DOST’s partner in making lives better for the Filipinos through health research,” said DOST Secretary Fortunato de la Peña.

Funded by the DOST - Philippine Council for Health Research and Development (PCHRD), AMDABiDSS-Health ultimately aims to benefit Local Health Agencies and Local Government Units (LGUs) in Mindanao through infectious disease control and monitoring component, Higher Education Institutions (HEIs) who will benefit from the training and workshops of each project, the Department of Health (DOH) that will be provided with data on population-level prevalence of COVID-19 faster and with lesser resources than individual testing, and other environmental health researchers who will be capacitated with knowledge and resources to push ONE HEALTH agenda in Infectious Disease research. 

The Department of Science and Technology-Philippine Council for Health Research and Development (DOST-PCHRD) recognizes the vital role of the research mentor who selflessly shares knowledge and skills, instills values and attitudes, and inspires those involved in the research process, thereby creating an enabling environment and contributing to capacity-building in research. 

The Best Mentor Award is offered biennially to recognize and reward mentors in health research who have built the capacities of researchers in the health sector and, in the process, propelled significant advances in the Philippine National Health Research System’s (PNHRS) thrusts as identified in the National Unified Health Research Agenda (NUHRA).

Awardees will be selected per cluster (Luzon, Visayas, Mindanao and NCR) and categorized according to their mentees (Undergraduate Students, Graduate Students and Junior/Early Career Researchers). Also, national winners will be chosen for each category who will be awarded during the PNHRS Week Celebration.

OBJECTIVE

Best Mentor Award recognizes excellence in mentorship that results in productivity of mentees in health research.

ELIGIBILITY

A. Who can nominate

The nominating party may be any of the following:

  • head of the nominee’s institution or immediate supervisor
  • colleague/s 
  • trainee/s 
  • student/advisee

Self-nomination is not allowed.

B. Who can be nominated

  1. must be a Filipino citizen
  2. must be with appropriate or relevant academic qualifications 
  3. must be actively involved in mentoring researchers/students or colleagues for at least 3 years 
  4. has a good track record as a researcher in terms of any of the following: publication, product development or policy formulation 
  5. professionally involved in health research activities either as a research program/project leader, principal and co-principal investigator, mentor/adviser/trainer, or author/co-author 
  6. actively involved in any health research activities in the last 5 years such as conduct of research training and extension work, paper presentations, fund generation, research promotion and networking, research agenda setting, and capacity-building activities

*Winners are ineligible for subsequent nominations, while non-winners are still eligible for nominations if they submit a new set of documents but not for consecutive calls of nomination

HOW TO NOMINATE

Submit the recommendation form (either personally delivered, by courier, or thru email) for initial screening to the regional consortium secretariat. (Please refer to the attached list of regional consortia and contact information)

For completed DOST-PCHRD and ASTHRDP scholars, submit entries to DOST-PCHRD for screening and endorsement of the PCHRD Scholar’s Society (PSS).

A. For the qualified nominees

The requirements below should be submitted strictly within the deadline 

1. Five (5) hard copies of the following documents:

1.1. Accomplished curriculum vitae of the nominee using the prescribed format for Best Mentor Award  

1.2. A narrative description (1,000-1,500 words) of the nominee’s mentoring activities using the guide questions provided, accompanied by supporting documents, e.g.  photos and other relevant documentation. 

1.3. Description of other achievements attained related to health research for the last 5 years, including supporting documents e.g., photocopy of certificates of recognition/awards/honors received by the nominee, which are relevant to the nominee’s eligibility criteria in Section IV. B Who can be nominated.

2. Cite names of 5 mentees, their achievements in research, and a narrative description of the nominee’s contribution to the success of each mentored research. 

To be submitted in a folder with proper tabbing and table of contents. Supplemental documents and/or verifications may be required as deemed necessary. 

B. Selection Criteria

There will be a review of nominations by the Cluster/National Selection Committee based on the following criteria:

c.2.1.  Research Guidance                   44%

  • Quantitative Indicators – refer to the no. of research mentees guided, advised or mentored by the candidate; also includes the nominee’s years of experience in mentoring. 
  • Qualitative indicators – to be decided by the evaluators; may include extent, quality/result of the research guidance/mentoring done e.g., awards and other forms of recognition received by the mentor and/or other mentees

c.2.2.  Track Record in Research              21%              

  • Publications refer to peer-reviewed journals during the last 5 years: 
                 ○ main author in a Philippine journal or international journal
                 ○ co-author in a Philippine journal or international journal

  • Awards received refer to recognition received for the research completed as:
                 ○ main author/principal investigator in the Philippines or International 
                 ○ 
co-author/member of a research team in the Philippines or International

  • Paper presented refers to the number of times the nominee presented the research work/paper in conference, workshop by recognized organization (either oral or poster)
  • Completed research covers completed unpublished researches over the last 5 years 

c.2.3.   Dedication in promoting research     20%                                                                                 

  • Types of active involvement in five years
                   ○ Teacher, adviser, panel member, critic
                   ○ 
Advocate of health-related policies
                   ○ 
Reviewer of refereed journal article/editor/member of editorial board/team 
                   ○ 
Member of professional organization/network
                   ○ 
Trainor in training courses/resource person/lecturer
                   ○ 
Research manager/director, coordinator, evaluator

  • Quality of active involvement within 5 years as:
                   ○ Teacher, adviser, panel member, critic
                   ○ 
Advocate of health-related policies
                   ○ 
Reviewer of refereed journal articles, editor/member of editorial team
                   ○ 
Trainor in training courses/resource person
                   ○ 
Research manager, coordinator, evaluator

c.2.4. Contribution towards a supportive research environment      10%
  • Providing research opportunities as:
                   ○ Organizer/initiator of program, project, policy
                   ○ 
Organizer/initiator/member of team for workshops, conferences
                   ○ 
Organizer/initiator/member of team for training courses
                   ○ 
Director/chair/administrator for research
                   ○ 
Study group leader
                   ○ 
Research team leader

 c.2.5. Other Criteria as agreed by the Evaluators 5%   

This may include awards/recognition received by mentees/advisees/students of the nominee or any agreed criteria; impact of R&D in terms of patenting, commercialization, and/or utilization of research results into policies and actions such as training modules developed, teaching manuals, community modules, contribution to national health development/equity and/or relevance of research results in health care delivery; etc


ANNOUNCEMENT OF WINNERS AND PRIZES

  • All qualified nominees will receive certificates of recognition. 
  • Cluster Winners from Luzon, Visayas, Mindanao and National Capital Region will receive respective cash prizes and plaques of recognition. 

                   Mentors of Undergraduate Students -               P50,000.00
                   
Mentors of Graduate Students -                        P50,000.00
                   
Mentors of Junior/Early Career Researchers -  P100,000.00


  • National Winners for each category will receive respective additional cash prizes and trophies which will be awarded during the PNHRS Week Celebration.
                   Mentors of Undergraduate Students -               P150,000.00
                   Mentors of Graduate Students -                        P150,000.00 
                   Mentors of Junior/Early Career Researchers -  P200,000.00


TIMETABLE


Activity


2021 Timeline

Call for nomination

March – May

Submission of recommendation form to the consortium

May 14, 2021

Submission of the endorsed recommendation forms to DOST-PCHRD

May 21, 2021

Submission of complete nominee’s documents to DOST-PCHRD

May – June 2021

Pre-screening of nominee’s complete documents

June

Selection Process

     -  Cluster

     -  National

June- July

Awarding of Winners

PNHRS Week

Celebration

(second week of August)