MD-PhD student publications hit record peak amid COVID-19 pandemic

Student outputs rise to record-high 33 health research publications amid the COVID-19 pandemic in 2020 and continue to climb with 22 articles published within the first four months of 2021, the MD-PhD in Molecular Medicine Program reports.

From the initial student publications in 2014, the number of research articles published with a UP College of Medicine-affiliated MD-PhD trainee or alumni reached 100 this year. This is a program milestone,” reported MD-PhD Program Coordinator Dr. Leslie Michelle Dalmacio and MD-PhD scholar Dr. Raniv Rojo.

Aiming to train research-oriented aspiring physicians and increase the pool of experts in biomedical research, the MD-PhD in Molecular Medicine Scholarship Program is the first and only dual degree program offered in the Philippines. It is a joint initiative of the Department of Science and Technology (DOST), Science Education Institute (SEI) through the Philippine Council for Health Research and Development (PCHRD), and the University of the Philippines (UP) College of Medicine.

The student outputs from the research courses are presented in various local and international science forums for dissemination and vetting as part of the program's mentoring, with more substantial outputs being published. 

The DOST-PCHRD is very proud of our MD-PhD scholars for reaching this milestone at a time where the country is battling with a pandemic. This is proof that investing in education has a transformative power in boosting research and innovation for societal development,” says PCHRD Executive Director Jaime Montoya.

The PCHRD acknowledges the productivity of the MD-PhD students as shown below:


Title

MD-PhDs in Publication

DOI/URL

Development of a loop-mediated isothermal amplification assay for detection of Trichomonas vaginalis

Reyes, John Carlo B.

https://doi.org/10.1016/j.diagmicrobio.2014.03.016

Leptospira-rat-human relationship in Luzon, Philippines

Zamora, Pia Regina Fatima C.

https://doi.org/10.1016/j.micinf.2014.07.001

Crude anthocyanin extract (CAE) from Ballatinao black rice hastens regeneration in Dugesia hymanae

Quebral, Elgin Paul B.

https://www.jpbms.info/index.php?option=com_docman&task=doc_download&gid=1206&Itemid=48

Not all Taua-tauas are alike: a morphological, molecular genetic, phytochemical, and anti-thrombocytopenic profiling of different Euphorbia hirta Linn. plants from the Philippines

de Paz, Sheriah Laine M.;
Sumalde, Angelo Augusto M.;
Cruz, Criselda Jean G.;
Robles, Joyce Ann H.

https://pjhrd.upm.edu.ph/index.php/main/article/view/26/0

The validity and applicability of loop-mediated isothermal amplification (LAMP) in the diagnosis of malaria in the Philippines

Poblete, Jonnel B.

https://pjhrd.upm.edu.ph/index.php/main/article/view/25

Crude anthocyanin extract (CAE) from Ballatinao black rice reduces acute lead toxicity in Daphnia magna

Ona, Kevin Austin L.

http://www.sciepub.com/JEPHH/abstract/4074

Epidemiologic study of Blastocystis infection in an urban community in the Philippines

Cadacio, Jessa Louise C.

https://doi.org/10.1155/2015/894297

Bioactivity of crude ethanolic and hexane extracts from Sargassum siliquosum JG agardh against fish pathogens

Tantengco, Ourlad Alzeus G.

https://doi.org/10.12692/ijb%2F6.9.55-61

Serologic characterization of leptospira among rats trapped in selected public markets in Iloilo City, Philippines

Zamora, Pia Regina Fatima C.

https://doi.org/10.47895/amp.v49i4.910

Cytotoxic activity of crude extracts and fractions from Premna odorata (Blanco), Artocarpus camansi (Blanco) and Gliricidia sepium (Jacq.) against selected human cancer cell lines

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/j.apjtb.2015.09.011

Subtype analysis of Blastocystis sp. isolates from human and canine hosts in an urban community in the Philippines

Reyes, John Carlo B.

https://doi.org/10.1016/j.parint.2016.02.009

Effect of Lactobacillus plantarum BS25 on cholesterol levels in vitro and in BALB/c mice (Mus musculus l.)

Tumampo, Cherie Joy F.

https://pjhrd.upm.edu.ph/index.php/main/article/view/104

Schistosomiasis in the Philippines: Challenges and some successes in control

Tabios, Ian Kim B.

https://www.tm.mahidol.ac.th/seameo/2016-47-4/11-CPH1413p651.pdf

Antibacterial activity of Vitex parviflora A. Juss. and Cyanthillium cinereum (L.) H. Rob. against human pathogens

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/S2222-1808(16)61173-8

Nephroprotective Effects of Imperata cylindrica Root Aqueous Extract (ICRAE) on Sprague-Dawley Rats with Gentamicin-induced Acute Kidney Injury

Poblete, Jonnel B.;
Santos, Bobbie Marie M.

https://pjhrd.upm.edu.ph/index.php/main/article/view/164

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition

Manalo, Rafael Vincent M.

https://doi.org/10.3390/biomedicines5020017

The Anti-Asthmatic Effect of the Combined Yerba Buena (Mentha arvensis Linn.) and Oregano (Coleus amboinicus Lour.) Leaves in BALB/c Mice Model of Allergic Asthma

Robles, Joyce Ann H.

https://doi.org/10.47895/amp.v51i2.589

Association of rs17095355 Polymorphism and Extrahepatic Biliary Atresia among Filipinos

Climacosa, Fresthel Monica M.

https://doi.org/10.47895/amp.v51i3.547

CD14/-159 and TNFα/-308 Promoter Polymorphisms are not associated with Development of Idiopathic Neonatal Hepatitis among Filipinos

San Juan, Florence Giannina F.;
Villanueva, Annavi Marie G.

https://doi.org/10.47895/amp.v51i3.553

Molecular interactions with redox sites and salt bridges modulate the anti-aggregatory effect of flavonoid, tannin and cardenolide moieties against amyloid-beta (1-42) in silico

Manalo, Rafael Vincent M.

https://doi.org/10.1007/s40203-017-0033-1

The differential effects of atorvastatin co-administered with ampicillin on the bacterial growth and biofilm formation of Staphylococcus aureus

Manalo, Rafael Vincent M.;
Josol, Vivien D.

https://doi.org/10.1016/j.cmrp.2017.08.002

Anti-staphylococcal and antioxidant properties of crude ethanolic extracts of macrofungi collected from the Philippines

Tantengco, Ourlad Alzeus G.

http://dx.doi.org/10.5530/pj.2018.1.19

Anastasis and the ER stress response: solving the paradox of the unfolded protein response in cancer

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.mehy.2017.09.013

Isolation and genetic detection of pathogenic Leptospira spp. from environmental soils and water in Central Luzon, Philippines

Tantengco, Ourlad Alzeus G.

https://doi.org/10.12980/APJTD.7.2017D7-220

Genetic comparison of Oncomelania hupensis quadrasi (Möllendorf, 1895) (Gastropoda: Pomatiopsidae), the intermediate host of Schistosoma japonicum in the Philippines, based on 16S ribosomal RNA sequence

Tabios, Ian Kim B.

https://journals.upd.edu.ph/index.php/sciencediliman/article/view/5805

Ethnomycological survey of macrofungi utilized by Ayta communities in Bataan, Philippines

Tantengco, Ourlad Alzeus G.

https://www.creamjournal.org/pdf/CREAM_8_1_9.pdf

Caffeine protects dopaminergic neurons from dopamine-induced neurodegeneration via synergistic adenosine-dopamine D2-like receptor interactions in transgenic Caenorhabditis elegans

Manalo, Rafael Vincent M.

https://doi.org/10.3389/fnins.2018.00137

The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.ejmhg.2017.07.004

Erythromycin exposure disrupts the life cycle stages of Aedes aegypti L. (Diptera: Culicidae)

Asis, Joannes Luke B.

https://doi.org/10.1007/s11270-018-3811-4

Garcinia binucao crude ethanolic leaf extract prevents alcoholinduced neurotoxic effects on learning, short-term memory, and motor functions in Drosophila melanogaster

Tantengco, Ourlad Alzeus G.;
Tan, Joanne Jennifer E.

https://www.japsonline.com/abstract.php?article_id=2747&sts=2

Medical students career choices and perceptions in family medicine and primary care

Tabios, Ian Kim B.;
Tantengco, Ourlad Alzeus G.

https://www.researchgate.net/publication/328281251_Medical_Students_Career_Choices_and_Perceptions_in_Family_Medicine_and_Primary_Care

Type II restriction modification system in Ureaplasma parvum OMC-P162 strain

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1371/journal.pone.0205328

Ethnobotanical survey of medicinal plants used by Ayta communities in Dinalupihan, Bataan, Philippines

Tantengco, Ourlad Alzeus G.

http://dx.doi.org/10.5530/pj.2018.5.145

Sex differences in the effects of Auricularia auricula-judae ethanolic extracts on the lifespan of Drosophila melanogaster during stress and non-stress conditions

Tantengco, Ourlad Alzeus G.

https://www.japsonline.com/abstract.php?article_id=2767

Antifungal activity of crude glycolated extracts of Solanum tuberosum L. (white potato) peelings against Candida and Aspergillus species

Tumampo, Cherie Joy F.

https://doi.org/10.47895/amp.v53i1.220

Exposure-dependent antimicrobial activity and oxidative properties of polymer-based graphene oxide nanocomposites

Perez, Joy Vanessa D.;
Rojo, Raniv D.

https://doi.org/10.4028/www.scientific.net/MSF.947.13

Infection rate of Schistosoma japonicum in the snail Oncomelania hupensis quadrasi in endemic villages in the Philippines: need for snail surveillance technique

Tabios, Ian Kim B.;
Gampoy, Eloina Faye S.

https://msptm.org/files/Vol36No2/402-411-Fornillos-RJC.pdf

Association of PIK3CA and MDM2 SNP309 with cervical squamous cell carcinoma in a Philippine population

Tantengco, Ourlad Alzeus G.

https://doi.org/10.31557/apjcp.2019.20.7.2103

Analysis of environmental DNA and edaphic factors for the detection of the snail intermediate host Oncomelania hupensis quadrasi

Tabios, Ian Kim B.

https://doi.org/10.3390/pathogens8040160

Current understanding and treatment of intra-amniotic infection with Ureaplasma spp

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1111/jog.14052

A case series of the dynamics of lipid mediators in patients with sepsis

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1002/ams2.443

Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines

Tabios, Ian Kim B.

https://doi.org/10.1371/journal.pone.0224617

Current status of neglected tropical diseases (NTDs) in the Philippines

Tabios, Ian Kim B.

https://doi.org/10.1016/j.actatropica.2019.105284

Cytosolic non-vesicular dopamine accumulation as the predominant mechanism for developing non-DOPA responsive parkinsonism in late-stage Huntington disease

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.mehy.2019.109377

Mutagenicity of Bulk, Aqueous and Organic Partitions of Air Particulate Matter in Differentially Ventilated Wards in a Public Urban Hospital

Nakpil, Aurora S.

https://neptjournal.com/upload-images/NL-72-48-(46)D-843.pdf

Fully automated preparation of 68 Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications 

Rojo, Raniv D.

https://doi.org/10.1016/j.apradiso.2019.108936

The genetics of bipolar disorder

Gordovez, Francis James A.

https://doi.org/10.1038/s41380-019-0634-7

First COVID-19 infections in the Philippines: a case report

Villanueva, Annavi Marie G.

https://dx.doi.org/10.1186%2Fs41182-020-00203-0

Antiviral effect of crude aqueous extracts from ten Philippine medicinal plants against Zika virus

Vista, Fatima Ericka S.

https://doi.org/10.47895/amp.v54i2.1501

A human erythrocyte-based haemolysis assay for the evaluation of human complement activity

King, Ruby Ann N.;
Climacosa, Fresthel Monica M.;
Santos, Bobbie Marie M.

https://doi.org/10.1177/0261192920953170

COVID-19 screening on a tuberculosis ward in Manila, the Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.1016/j.jctube.2020.100167

Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M

Poblete, Josept Mari S.

https://doi.org/10.1152/ajpendo.00174.2019

Oncomelania hupensis quadrasi: snail intermediate host of Schistosoma japonicum in the Philippines

Tabios, Ian Kim B.

https://doi.org/10.1016/j.actatropica.2020.105547

Epidemiological and clinical characteristics of patients with suspected COVID-19 admitted in Metro Manila, Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.1186/s41182-020-00241-8

In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model

Perez, Joy Vanessa D.

https://doi.org/10.1039/d0bm00414f

Novel variants in hearing loss Genes and associations with audiometric thresholds in a multi-ethnic cohort of US patients with cochlear implants

Sumalde, Angelo Augusto M.

https://doi.org/10.1097/mao.0000000000002671

Detection of human pegivirus (HPgV) infection among Filipino children with decompensated liver disease secondary to biliary cirrhosis and liver transplant pediatric patients

Aquino, Inah Marie C.

https://doi.org/10.47895/amp.v54i4.1897

COVID-19 screening for healthcare workers in a tertiary infectious diseases referral hospital in Manila, the Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.4269/ajtmh.20-0715

Prevalence of urolithiasis by ultrasonography among patients with gout: a cross-sectional study from the UP-Philippine General Hospital

Abrilla, Aedrian A.

https://doi.org/10.2147/rru.s268700

Genomic and proteomic mutation landscapes of SARSCoV2

Badua, Christian Luke D.C;
Baldo, Karol Ann T.

https://doi.org/10.1002/jmv.26548

Detection of Vibrio parahaemolyticus in fish samples from selected wet markets in Laguna, Philippines, using loop-mediated isothermal amplification (LAMP) and real-time polymerase chain reaction (qPCR)

Teh, Treena Rica D.

https://www.philsciletters.net/2020-special-issue-8/

Prevalence of Entamoeba histolytica and Entamoeba dispar among residents of an urban slum area in Manila, Philippines as detected by the polymerase chain reaction

Aquino, Inah Marie C.

https://annals-parasitology.eu/go.live.php/download_default/D1729/prevalence-of-ientamoeba-histolyticai-and-ientamoeba-dispari-among-residents-of-an-urban-slum-area-in-manila-philippines-as-detected-by-the-polymerase-chain-reaction.html

Understanding nanoparticle toxicity to direct a safe-by-design approach in cancer nanomedicine

Perez, Joy Vanessa D.

https://doi.org/10.3390/nano10112186

Effects of a gestational level of estradiol on cellular transition, migration, and inflammation in cervical epithelial and stromal cells

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1111/aji.13370

Environmental pollutant exposure can exacerbate COVID-19 neurologic symptoms

Reyes, Michael Sigfrid S.

https://doi.org/10.1016/j.mehy.2020.110136

Development and characterization of polymeric peptides for antibody tagging of bacterial targets

Climacosa, Fresthel Monica M.;
King, Ruby Ann N.;
Santos, Bobbie Marie M.

https://doi.org/10.2174/0929866527666200427212940

Hydranencephaly: clinical features and survivorship in a retrospective cohort 

Reyes, John Carlo B.

https://doi.org/10.1016/j.wneu.2020.09.029

Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone fibrous composites

Perez, Joy Vanessa D.;
Rojo, Raniv D.

https://doi.org/10.1016/j.mtla.2020.100874

Primary Care Orientation of Family Practice in the Philippines: Cross-sectional Study in Pilot Sites

Tabios, Ian Kim B.

https://www.researchgate.net/profile/Leilanie-Nicodemus-2/publication/348758671_Primary_Care_Orientation_of_Family_Practice_in_the_Philippines_Cross-sectional_Study_in_Pilot_Sites/links/600fb2a4299bf14088c09375/Primary-Care-Orientation-of-Family-Practice-in-the-Philippines-Cross-sectional-Study-in-Pilot-Sites.pdf

Identification of Class I HLA alleles in anonymized cell therapy specimens through real-time PCR with meltcurve analysis

Tan, Joanne Jennifer E.

https://www.psbmb.org/uploads/1/0/1/3/101342864/article_4_january-december_2020_volume_1_issue_1_2.pdf

Contractile function of the cervix plays a role in normal and pathological pregnancy and parturition

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/j.mehy.2020.110336

Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson's disease

Manalo, Rafael Vincent M.

https://doi.org/10.1080/13880209.2020.1791192

Policy analysis on determining hospital bed capacity in light of Universal Health Care

Buan, Ara Karizza G.

https://doi.org/10.47895/amp.v54i6.2596

A call for an evidence-informed criteria selection to guide equitable health investments in the era of Universal Health Care: policy analysis

Buan, Ara Karizza G.

https://doi.org/10.47895/amp.v54i6.2587

Addressing primary care inequities in underserved areas of the Philippines: a review

Buan, Ara Karizza G.

https://doi.org/10.47895/amp.v54i6.2578

In silico prediction of SARS-CoV-2 epitopes for vaccine development

Marco, Kitz Paul D.;
Llagas, Julia Patricia B.

https://pjhrd.upm.edu.ph/index.php/main/article/view/382

An optimized de Man Rogosa Sharpe-McCoy’s 5A medium formulation for the in vitro screening of cytotoxic effects by probiotic candidates against colorectal cancer cells

Badua, Christian Luke D.C

https://www.philsciletters.net/2020-139/

Molecular epidemiology of coxsackievirus A6 causing hand-foot-and-mouth disease in the Philippines, 2012–2017

Climacosa, Fresthel Monica M.

https://doi.org/10.1016/j.ijid.2020.09.1299

Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions

Perez, Joy Vanessa D.

https://doi.org/10.1002/mp.14601

Recent advances in nanomedicine for the diagnosis and treatment of prostate cancer bone metastasis

Perez, Joy Vanessa D.;
Rojo, Raniv D.

https://doi.org/10.3390/molecules26020384

Effects of brief adjunctive metformin therapy in virologically suppressed HIV-infected adults on polyfunctional HIV-specific CD8 T cell responses to PD-L1 blockade

Padua, Ana Joy P.

https://doi.org/10.1089/aid.2020.0172

Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains

Cruz, Christian Alfredo K.

https://doi.org/10.1016/j.tranon.2020.100940

The role of genital mycoplasma infection in female infertility: a systematic review and meta-analysis

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1111/aji.13390

Anti-inflammatory drugs and the renin-angiotensin-aldosterone system: current knowledge and potential effects on early SARS-CoV-2 infection

Manalo, Rafael Vincent M.

https://doi.org/10.1016/j.virusres.2020.198190

Barriers to online learning in the time of COVID-19: a national survey of medical students in the Philippines

Reyes, John Carlo B.

https://doi.org/10.1007/s40670-021-01231-z

Virgin coconut oil attenuates deficits in rats undergoing transient cerebral ischemia

Climacosa, Fresthel Monica M.

https://doi.org/10.47895/amp.v55i1.2938

Philippine rice wine (tapuy) made from Ballatinao black rice and traditional starter culture (Bubod) showed high alcohol content, total phenolic content, and antioxidant activity

Dela Rosa, Jared Gabriel L.

https://doi.org/10.1590/fst.45120

Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice

Girasol, Mark John G.;
Grecia, Lordom Reno C.

https://doi.org/10.1016/j.exppara.2020.108049

Direct saliva versus conventional nasopharyngeal swab qRT-PCR to diagnose SARS – CoV2: validity study

Abrilla, Aedrian A.

https://doi.org/10.9734/ajrid/2021/v6i230193

Cactus: chemical, nutraceutical composition and potential bio-pharmacological properties

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1002/ptr.6889

Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1093/biolre/ioab058

If not COVID-19 what is it? Analysis of COVID-19 versus common respiratory viruses among symptomatic health care workers in a tertiary infectious disease referral hospital in Manila, Philippines

Villanueva, Annavi Marie G.

https://doi.org/10.3390/tropicalmed6010039

Molecular epidemiologic analysis of Mycobacterium tuberculosis among prison inmates in selected prisons in the Philippines

Malabad, John Carlo M.

https://philjournalsci.dost.gov.ph/images/pdf/pjs_pdf/vol150no2/molecular_epidemiologic_analysis_of_mycobacterium_tuberculosis_.pdf

Molecular epidemiology of Mycobacterium tuberculosis in adult Filipino TB-HIV co-infected patients

Malabad, John Carlo M.

https://doi.org/10.5588/ijtld.20.0878

Organ-on-chip of the cervical epithelial layer: A platform to study normal and pathological cellular remodeling of the cervix

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1096/fj.202002590rrr

Progesterone alters human cervical epithelial and stromal cell transition and migration: Implications in cervical remodeling during pregnancy and parturition

Tantengco, Ourlad Alzeus G.

https://doi.org/10.1016/j.mce.2021.111276

Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice

Rojo, Raniv D.;
Perez, Joy Vanessa D.

https://doi.org/10.1080/02656736.2021.1914873

Prevalence and prognostic associations of cardiac abnormalities among hospitalized patients with COVID19: a systematic review and metaanalysis

Lintao, Ryan C.V.

https://doi.org/10.1038/s41598-021-87961-x

Efficacy of fluvastatin and aspirin for prevention of hormonally insensitive breast cancer

Rojo, Raniv D.

https://doi.org/10.1007/s10549-021-06229-0

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Tantengco, Ourlad Alzeus G.;
Robles, Joyce Ann H.

https://doi.org/10.3390/plants10050846

Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Abrilla, Aedrian A.

https://doi.org/10.1016/j.diabres.2021.108824

Characteristics and Factors Associated with Mortality of 200 COVID-19 Patients at a Philippine COVID-19 Tertiary Referral Center

Poblete, Jonnel B.

https://doi.org/10.47895/amp.v55i2.2845